Table 1. The role of A/AR in apoptosis of prostate cancer in cellular models.
|
Prostate cell lines |
Treatment |
Time |
Molecular mechanisms |
Ref. |
|
PC-3(AR)13 |
1 nM DHT |
6 days |
↓ cell cycle, ↓ G1 to S, ↓ G2M |
[30] |
|
PC-3(AR)2 |
0.1 nM, 1nM, 10 nM DHT |
3-6 days |
↓ Akt/PI3K, ↓ cell cycle, ↓ G1 to S, ↓ G2M |
[38] |
|
104-R1, 104-R2 |
0.1 nM, 1nM, 10 nM R1881 |
6 days |
↑ Bax, ↓ Bcl-2, ↑ p27, ↓ c-myc, |
[39] |
|
DU-145 (AR-RB) |
10 nM DHT |
1 day |
↑RB, ↑Bax, ↓Bcl-2, ↑p27, ↑p21, ↑Casapase-3 |
[40] |
|
LNCaP, LNCaP-RelAp65 |
10 nM DHT and 1nM TPA |
2 days & 1 day |
↑IkB, ↓ NF-kB, ↑JNK, |
[41] |
|
HPr-1AR |
5-10 nM Mibolerone |
2-3 days |
↑p21, ↑ p27, ↓ c-myc, ↓ Bcl-2 |
[42] |
DHT: Dihydrotestosterone. R1881: Methyltienolone (sysnthrtic andrgen), TPA: Tetradecanoylphorbolacetate