Table 2. Effect of C. maxima ethanol seed extracts on levels of fasting blood glucose on alloxan-induced diabetes in rats.
|
|
|
Blood glucose levels (mmol/L) |
|
|
|||||
Treatment |
Baseline |
0 h |
2 h |
4 h |
6 h |
24 h |
Day 7 |
Day 14 |
Day 21 |
Day 28 |
Non-diabetic |
5.12±0.20a |
4.88±0.34b |
4.94±0.27c |
4.68±0.32c |
5.04±0.28d |
5.08±0.18d |
5.06±0.29d |
5.28±0.19c |
5.20±0.19d |
5.04±0.22d |
Diabetic |
5.20±0.21a |
28.90±0.58a |
29.16±0.74a |
29.78±0.86a |
29.48±0.43a |
30.58±0.68a |
30.08±0.71a |
31.54±1.97a |
29.42±0.75a |
29.62±0.50a |
Glibenclamide |
5.20±0.23a |
30.46±0.84a |
25.14±0.35b |
22.04±0.56b |
19.92±0.34c |
19.78±0.38c |
13.28±0.54bc |
13.06±0.55b |
12.16±0.44b |
11.89±0.30b |
200mg/kg bw EtE |
5.24±0.21a |
29.04±0.39a |
26.00±0.48b |
23.54±0.38b |
22.64±0.40b |
22.02±0.30b |
14.86±0.28b |
12.68±0.20b |
11.38±0.26bc |
10.72±0.14bc |
400mg/kg bw EtE |
5.20±0.23a |
29.56±0.67a |
26.52±0.52b |
22.64±0.33b |
21.00±0.45c |
18.34±0.32c |
11.58±0.32c |
10.16±0.25b |
10.30±0.32c |
10.14±0.25c |
Using one-way ANOVA and Tukey's multiple comparisons, the means with mean±standard error that do not share a lowercase superscript letter along the column vary significantly (p<0.05). Non-diabetic = normal control; diabetic = alloxan treated-negative control; glibenclamide = reference drug treated to diabetic rats; EtE = ethanol extract treated to diabetic rats.