Antioxidant and hepatoprotective effects of Solanum villosum leaf extracts against acetaminophen-induced mouse model of hepatotoxicity

Table 2. Effect of extract on liver function markers in ACP-induced mice model.

Parameters	Control	ACP	ACP+Sily	ACP+SVE30	ACP+SVE100	ACP+SVE300	ACP+SVE500
ALP (U/L)	24.25±1.69^a	60.63±6.63^b	37.40± 2.90^c	15.90±0.83^a	15.98±0.97^a	18.49±0.31^a	17.19±0.42^a
ALT (U/L)	38.86±8.11^a	435.43±31.55^b	56.66±1.71^a	230.77±6.96^c	191.58±8.35^c	59.87±4.10^a	41.62±1.00^a
AST (U/L)	277.80±4.64^ac	727.45±22.73^b	235.07±2.88^a	363.50±15.91^d	305.25±3.97^c	303.52±2.72^c	265.62±6.53^ac
γ-GGT (U/L)	0.80±0.03^a	5.02±0.17^b	2.50±0.06^c	2.82±0.10^d	3.14±0.18^d	3.53±0.08^d	3.63±0.04^d
TP (g/L)	67.58±1.40^a	41.55±1.87^b	44.12±2.15^b	39.72±2.13^b	43.87±1.28^b	46.49±0.80^b	47.83±0.95^b

Groups are Control, ACP (acetaminophen 300 mg/kg), ACP+Sily (25 mg/kg bw), ACP+SVE 30 mg/kg, ACP+SVE100 mg/kg, ACP+SVE300 mg/kg, and ACP+SVE500 mg/kg. Values are reported as mean ± SEM for five mice. Means with different superscript letters are statistically significant by ANOVA and Tukey’s post hoc test across the table at 95% level (P≤0.05). SEM = standard error of mean. bw= body weight. S. villosum leaf MeOH extract (SVE), Alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GGT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total protein (TP).