Table 1. Significantly altered metabolites in diabetic samples compared to non-diabetic samples.
|
M/Z ratio |
Fold Change |
Direction of change |
P-value |
KEGG ID |
Name of Metabolites |
Formula |
|
568.1 |
2.434 |
Elevated |
0.005969 |
C11583 |
4-Glutathionyl cyclophosphamide |
C17H30Cl2N5O8PS |
|
288 |
1.7982 |
Elevated |
0.009842 |
C03090 |
5-Phosphoribosylamine |
C5H12NO7P |
|
701.2 |
8.893 |
Elevated |
0.013466 |
C00006 |
Nicotinamide adenine dinucleotide phosphate (NADP+) |
C21H29N7O17P3 |
|
106.1 |
2.2032 |
Elevated |
0.019792 |
C03771 |
2-Oxo-5-guanidinopentanoate (2-Oxoarginine) |
C6H11N3O3 |
|
332.2 |
3.018 |
Elevated |
0.041538 |
C05498 |
11-beta-Hydroxyprogesterone |
C21H30O3 |
|
272.2 |
0.52196 |
Reduced |
6.03E-06 |
C01137 |
S-Adenosylmethioninamine |
C14H23N6O3S |
|
284.1 |
0.53858 |
Reduced |
0.000114 |
C00387 |
Guanosine |
C10H13N5O5 |
|
414.2 |
0.58181 |
Reduced |
0.000222 |
C06508 |
Adenosyl cobinamide |
C58H84CoN16O11 |
|
415.1 |
0.39185 |
Reduced |
0.00031 |
C00255 |
Riboflavin |
C17H20N4O6 |
|
371.2 |
0.45837 |
Reduced |
0.001101 |
C05011 |
4-Hydroxytamoxifen |
C26H29NO2 |
|
C16545 |
Tamoxifen N-oxide |
C26H29NO2 |
||||
|
C16544 |
alpha-Hydroxytamoxifen |
C26H29NO2 |
||||
|
C00473 |
Retinol (Vitamin A) |
C20H30O |
||||
|
C16682 |
9-cis-Retinol |
C20H30O |
||||
|
C00899 |
11-cis-Retinol |
C20H30O |
||||
|
385.2 |
0.61508 |
Reduced |
0.005507 |
C00735 |
Hydrocortisone (Cortisol) |
C21H30O5 |
|
C05469 |
4,5beta-Dihydrocortisone |
C21H30O5 |
||||
|
C01124 |
18-Hydroxycorticosterone |
C21H30O5 |
||||
|
C16677 |
all-trans-4-Hydroxyretinoic acid |
C20H28O3 |
||||
|
C16680 |
all-trans-5,6-Epoxy-5,6-dihydroretinoic acid |
C20H28O3 |
||||
|
648.1 |
0.38831 |
Reduced |
0.005577 |
C00003 |
Nicotinamide adenine dinucleotide (NAD+) |
C21H28N7O14P2 |
|
C00857 |
Nicotinic acid adenine dinucleotide (Deamino-NAD+) |
C21H28N7O14P2 |
||||
|
620.3 |
0.52151 |
Reduced |
0.010719 |
C03541 |
Tetrahydrofolyl-polyglutamate |
C24H30N8O9(C5H7NO3)n-2 |
|
513.3 |
0.24896 |
Reduced |
0.026634 |
C22112 |
4-alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol |
C28H44O3 |
|
C00828 |
Menaquinone (Vitamin K2) |
C16H16O2(C5H8)n |
||||
|
275.1 |
0.48167 |
Reduced |
0.027142 |
C05841 |
beta-D-Ribosylnicotinate |
C11H14NO6 |
|
372.2 |
0.51342 |
Reduced |
0.040608 |
C00445 |
5,10-Methenyltetrahydrofolate |
C20H22N7O6 |
|
334.1 |
0.59275 |
Reduced |
0.048136 |
C02538 |
Estrone 3-sulfate |
C18H22O5S |