Table 1. Comparison of the means of clinical parameters between patients and a control group.
|
Parameters |
HC No=60 Mean± SD |
Patients’ groups No =180 |
P value |
|
|
SCH No=60 Mean± SD |
OH No=60 Mean± SD |
|||
|
Age (years)
|
34.12±8.69 35.13±7.27 35.65±5.0 |
36.65±12.29 36.90±6.38 41.89±8.88 |
35.65±10.27 37.10±9.02 39.90±11.94 |
------------ |
|
Sex F/M |
44/16 |
50/10 |
50/10 |
------------ |
|
BMI (Kg/m 2) |
26.60±4.67 |
29.06±4.63 |
32.38±6.15 |
0.010a 0.001b 0.001c |
|
T3 (ng/mL) |
2.30±0.65 |
1.97±0.37 |
1.68±0.74 |
0.003a 0.001b 0.009c |
|
T4 (ng/mL) |
103.42±15.90 |
102.93±22.78 |
74.15±23.54 |
0.898a 0.001b 0.001c |
|
TSH (µIU/mL) |
3.70±2.90 |
8.28±3.79 |
21.53±19.24 |
0.003a 0.001b 0.001c |
|
FSG (mg/dL) |
90.15±6.75 |
99.48±9.46 |
111.25±10.51 |
0.001a 0.001b 0.001c |
|
Insulin (µU/mL) |
7.13±2.33 |
11.20 ±2.37 |
13.00±2.19 |
0.001a 0.001b 0.001c |
|
HOMA-IR |
1.56±0.41 |
2.08±0.89 |
3.06±0.91 |
0.001a 0.001b 0.001c |
|
HOMA-β |
121.35±22.99 |
110.26±10.63 |
109.22±11.81 |
0.724a 0.001b 0.001c |
|
T-CHO (mg/dL) |
168.17±17.49 |
169.23 ±14.44 |
187.07±24.79 |
0.733a 0.001b 0.001c |
|
TG (mg/dL) |
105.72±22.72 |
144.58 ±36.56 |
161.82±47.07 |
0.001a 0.001b 0.011c |
|
LDL-C (mg/dl) |
111.57±16.97 |
117.30±12.99 |
132.42±16.32 |
0.045a 0.001b 0.001c |
|
VLDL-C (mg/dL) |
21.14±4.54 |
28.92±7.31 |
32.36±9.41 |
0.001a 0.001b 0.011c |
|
HDL-C (mg/dl) |
35.45±6.85 |
23.02±4.42 |
22.28±4.84 |
0.001a 0.001b 0.464c |
|
IL-33 (pg/ml) |
0.05±0.08 |
0.09±0.0.09 |
0.22±0.16 |
0.036a 0.001b 0.001c |
Data represented as Mean ±SD: standard deviation, NS= non- significantly differences at (P>0.05). *=significant differences at (P≤ 0.05, OH: OVERT hypothyroidism, SCH: subclinical hypothyroidism, HC: healthy group No: number patients. a =significantly difference between values in group SUB and group CH. b=significantly difference between values in group OH and CH. c =significantly difference between values in group 3 and 2 BMI: body mass index, FBG: fasting blood glucose, HOMA-IR: hemostasis model assessment-In’s resistance assessment, HOMA-β%: hemostasis model assessment- beta cell percentage. TG: triglyceride, HDL-C: High-density lipoprotein-cholesterol, LDL-C: low-density lipoprotein-cholesterol.