Drug

Disease

Method of preparation

Key findings

Ref.

Dorzolamide HCl

Glaucoma

Coacervation phase separation method

An in-vitro investigation on male albino rabbit eyes demonstrated lower intraocular pressure and higher bioavailability than Trusopt eye drop.

[62]

Brimonidine tartrate

Glaucoma

Coacervation phase separation method

In-vivo studies on albino rabbits showed sustained drug release and an increase in mean residence time, which ultimately leads to an increase in bioavailability compared to the marketed formulation.

[49]

Voriconazole

Fungal infections like fungal keratitis

Coacervation phase separation method

The formulation was found to be stable and provide sustained release of formulation for the managing` of fungal infection when compared with the marketed formulation of voriconazole eye drops.

[98]

Ketoconazole

Ocular keratitis

Coacervation phase separation method

It shows a promising approach in increasing corneal contact, permeation, and retention time in the eye, resulting in sustained action and enhanced bioavailability than ketoconazole non-niosomal form.

[99]

Curcumin loaded proniosomal gel

Ocular inflammation

Coacervation phase separation method

The formulation showed enhanced permeability higher than curcumin dispersion and its lyophilized form.

[41]

Tacrolimus proniosomes

Corneal graft-versus-host disease, conjunctivitis, dry eye, uveitis

Coacervation phase separation method

In- vitro studies in rabbit cornea for 21 days showed enhanced precorneal permeation and retention of tacrolimus.

[71]

Timolol maleate

Glaucoma

Coacervation phase separation method

Proniosomes were found, an alternative to conventional eye drops as they exhibit good penetrability with sustained release action.

[100]

Levofloxacin proniosome gel

Bacterial conjunctivitis

Coacervation phase separation method

It enhances spread ability in the eye and increases ocular contact time by releasing the drug in a sustained manner.

[67]

Acetazolamide proniosomal gel

Glaucoma

Coacervation phase separation method

Acetazolamide proniosomal gel improved ocular medication delivery by prolonging drug release.

[101]

Betaxolol hydrochloride proniosomal gel

Glaucoma

Slurry method

The formulation showed good entrapment efficiency with an increase in ocular residence time.

[102]

Lomefloxacin HCl proniosomal gel

Bacterial conjunctivitis

Coacervation-phase separation method

In-vitro studies in rabbits found an increase in the therapeutic effectiveness of lomefloxacin by prolonging corneal retention and penetration.

[66]