Table 6. Effects of epitopic missense variants of VEGFA on VEGFA-VEGFR2 interaction.
|
VEGFA variants |
∆∆G (kcal/mol)a |
||
|
mCSM-PPI2 |
SAAMBE-3D |
MutaBind2 |
|
|
R82W |
0.163 |
0.44 |
0.86 |
|
R82Q |
0.102 |
1 |
0.48 |
|
I83L |
0.76 |
0.51 |
0.74 |
|
Q87R |
-0.296 |
0.31 |
0.18 |
|
G88S |
-0.194 |
0.04 |
0.78 |
|
G92R |
0.248 |
0.18 |
0.71 |
a Positive value of ∆∆G indicate decreasing affinity.