Table 8. Effects of the rs139876191 variant on insulin resistance.
|
Insulin resistance indices |
Wild type del/del N=44 |
Carrier del/ins N=16 |
P- value |
|
FBG (mg/dl) |
105.3 ± 32.7 |
98.125 ± 12.1 |
0.737 |
|
FSI (μIU/ml) |
10.88 ± 6.37 |
11.21 ± 4.85 |
0.529 |
|
HOMA2-B % |
108.17 ± 82.17 |
109.2 ± 57.3 |
0.538 |
|
HOMA2-S% |
96.40 ± 59.60 |
79.5 ± 34.97 |
0.573 |
|
HOMA2-IR |
1.4 ± 0.86 |
1.46 ± 0.62 |
0.579 |
Linear regression analysis was performed for evaluating the effect of the HMGA1 variant on HOMA-IR, adding age, gender, and BMI as covariates. FBG, fasting blood glucose. FSI, Fasting serum insulin. HOMA2-B%, Homeostatic model assessment method 2 for beta cells function. HOMA2-S%, Homeostatic model assessment method 2 for insulin sensitivity. HOMA2-IR, Homeostatic model assessment method 2 for insulin resistance.