Pharmacological agents

Animals used

Challenges

Results

Ref.

BN 5021

Mouse

Intravenous LPS

Positive

[83]

TAK-242

Mouse

Intraperitoneal LPS

Positive

[84]

Tifacogin

Baboon

Viable intravenous E. coli

Positive

[85]

BB-882

Mouse

Intravenous LPS

Positive

[86]

Tifacogin

Mouse

Cecal ligation and puncture (CLP)

Positive

[87]

IL1-RA

Mouse

Intraperitoneal LPS

Positive

[88]

Methylprednisolone sodium succinate

Baboon

Viable intravenous E. coli

Positive

[89]

Lenercept

Baboon

Viable intravenous E. coli

Positive

[90]

Tifacogin

Rabbit

Peritonitis caused by E. coli 018: K+

Positive

[91]

CDP571

Baboon

Viable intravenous E. coli

Positive

[92]