Effect of KISS1 gene variants (rs372790354 G>A and rs4889 G>A) on kisspeptin in patients with polycystic ovary syndrome in Iraq

Table 13. The influence of rs4889 G>A polymorphism of KISS1 gene on the mean differences of characteristics and parameters between genotypes patient (normal weight and obese) group.

Parameter	Group	Genotype of rs4889		(P-value)
Parameter	Group	GA Mean ±SE	AA Mean ±SE	(P-value)
No. of GA/AA	Normal weight	18	9
No. of GA/AA	Obese	13	7
WHR	Normal weight	0.89 ±0.01	0.90±0.02	GA<0.01 AA=0.009
WHR	Obese	1.0±0.02	1.02±0.03	GA<0.01 AA=0.009
LH (mIU/ml)	Normal weight	8.79 ±1.11	11.58±3.1	GA=0.54 AA=0.51
LH (mIU/ml)	Obese	10.3±2.62	8.98±1.82	GA=0.54 AA=0.51
FSH (mIU/ml)	Normal weight	6.06±1.6	3.8±0.43	GA=0.66 AA=0.62
FSH (mIU/ml)	Obese	5.13±0.93	4.22±0.51	GA=0.66 AA=0.62
LH/FSH Ratio	Normal weight	2.11±0.28	3.18±0.77	GA=0.24 AA=0.33
LH/FSH Ratio	Obese	1.94±0.55	2.04±0.35	GA=0.24 AA=0.33
kisspeptin ng/L	Normal weight	300.4±38.3	1062±187	GA=0.09 AA=0.007
kisspeptin ng/L	Obese	363.7±20	372.2±51.4	GA=0.09 AA=0.007
F.Testosterone (pg/ml)	Normal weight	2.16±0.17	1.98±0.31	GA=0.32 AA=0.07
F.Testosterone (pg/ml)	Obese	2.53±0.37	3.34±0.68	GA=0.32 AA=0.07
DHEA (μg/dl)	Normal weight	312.9±35.3	402±67.4	GA=86 AA=0.42
DHEA (μg/dl)	Obese	323.3±24.2	330.9±46.6	GA=86 AA=0.42

*Significant differences at P-Value ≤ 0.05