Table 2. Effect of ramipril on biochemical parameters in plasma and liver in alloxan-induced diabetes rats.
|
Parameters |
Groups |
||||
|
Control |
Control+Ramipril |
Alloxan |
Alloxan+Ramipril |
||
|
Plasma parameters |
|||||
|
MDA (nmol/ml) |
16.33±1.26a |
19.82±1.54a |
35.92±2.87b |
24.17±2.76a |
|
|
NO (nmol/ml) |
7.63±0.51a |
5.87±0.73a |
10.93±0.93b |
7.52±0.73b |
|
|
APOP (nmol/ml) |
384.44±27.78a |
270.16±18.25a |
575.71±36.01b |
361.43±21.75a |
|
|
Catalase (U/min) |
7.00±0.63a |
6.00±0.37a |
4.00±0.37b |
4.50±0.76b |
|
|
GSH (nmol/ml) |
11.72±0.77a |
11.13±0.96a |
6.77±0.33b |
11.17±0.47a |
|
|
SOD (U/L) |
35.57±4.04a |
41.27±3.26a |
17.01±3.05b |
29.13±4.28a |
|
|
AST(U/L) |
31.58±2.87a |
33.02±2.65a |
64.60±5.33b |
45.94±4.26a |
|
|
ALT(U/L) |
27.28±4.11a |
28.71±4.26a |
47.37±2.94b |
37.18±2.90b |
|
|
ALP(U/L) |
50.74±5.15a |
45.14±3.79a |
81.43±5.81b |
53.08±6.38a |
|
|
Liver parameters |
|||||
|
MDA (nmol/ml) |
43.77±1.20a |
47.36±2.31a |
69.67±3.79b |
55.69±3.17b |
|
|
NO (nmol/ml) |
14.38±1.81a |
7.54±1.15a |
22.27±0.49b |
11.12±1.91a |
|
|
APOP (nmol/ml) |
653.02±43.97a |
683.1±43.39a |
881.59±60.47b |
548.25±37.43a |
|
|
Catalase (U/min) |
10.00±1.29a |
15.00±3.24a |
6.67±1.05b |
10.83±0.83b |
|
|
GSH (nmol/ml) |
18.41±1.85a |
21.03±2.65a |
10.55±0.59b |
16.15±2.92a |
|
|
SOD (U/L) |
57.73±3.68a |
84.76±4.39a |
33.39±5.11b |
47.88±7.28a |
|
|
MPO (U/L) |
2.02±0.05a |
1.35±0.18a |
3.85±0.13b |
1.51±0.23a |
|
Values are presented as mean±SEM. N=5-6 in each group or otherwise specified. One way ANOVA with Newman-Keuls tests were done as post hoc test. Values are considered significance at p<0.05.