Group

Treatment

Percent inhibition of pain after treatment

Early phase

Late phase

Negative control 

DMSO 5%  

100.00±0.00^a

100.00±0.00^a

Normal control

Formalin 2.5%

0.00±0.00^e

0.00±0.00^f

Positive control

Formalin 2.5% + Paracetamol (50mg/kg bw)

67.75±2.80^b

56.84±1.30^b

Experimental groups

A

 Formalin + C. pareira (50mg/kg bw)

37.21±5.81^d         

16.26±3.23^e

B

 Formalin + C. pareira (100mg/kg bw)

58.20±5.66^bc

27.37±1.54^d

C

 Formalin + C. pareira (150mg/kg bw)

53.26±5.14^bcd

38.25±3.28^c

D

 Formalin + C. pareira (200mg/kg bw)

49.21±3.00^cd             

28.07±1.85^cd

E

 Formalin + C. pareira (250mg/kg bw)

40.21±3.43^d

32.40±3.65^cd

Values are expressed as Mean ± SEM. Statistical comparison was made within a column. Values with the same superscript are not significantly different (p>0.05).