Drug Target

Target Category

Target Type

Function

Ref.

M2 protein

Ion Channel

Structural viral channel protein

Allows hydrogen ions to enter inside viral envelop which is needed for viral uncoating

[28,29]

Neuraminidase

Enzyme

Non-structural viral protein

Digests HA receptors to allow virus to infect new cells and also digests neuraminic acid in respiratory mucus

[30,31]

RNA-dependent RNA polymerase (RdRp)

Enzyme

Non-structural viral protein

Replication and transcription of viral RNA and mRNA

[32,33]

Hemagglutinin

Envelop protein

Structural viral protein

Attaches to specific receptors on host cell surface to fuse with host plasma membrane

[34,35]

Nucleoprotein

Protein-nucleic acid complex

Non-structural viral protein-nucleic acid complex

Prevents digestion of viral RNA by cellular RNases

[36-38]

DNA- dependent DNA polymerase (DdDp)

Enzyme

Non-structural viral protein

Replicates viral genome

[39,40]

Helicase-primase complex

Enzyme complex

Non-structural viral protein complex

Unwinds ds viral DNA and initiates DNA replication

[41,42]

Protease

Enzyme

Non-structural viral protein

Cleaves specific peptide bonds in viral polyprotein precursors

[43,44]