Table 2. The effect of H. coccineum leaves extract with reference drug Loperamide on intestinal motility in mice by using charcoal as a marker.
|
Treatment (mg/kg) |
Total Length of Intestine (cm) |
Distance Travel by Charcoal (cm) |
Peristalsis Index (%) |
Inhibition (%) |
|
Control |
50.33 ± 0.33 |
43.66 ± 2.91 |
86.69 ± 5.23 |
- |
|
Loperamide (5) |
52.66 ± 0.33 c |
22.66 ± 1.45 c |
43.04 ± 2.79 d |
48.09 |
|
MEHCL 200 |
56 ± 1.15 c |
33.33 ± 1.76 b |
59.52 ± 2.76 c |
23.67 |
|
MEHCL 400 |
60 ± 1.00 d |
25.33 ± 1.33 c |
42.22 ± 3.00 d |
41.98 |
Results represented in Mean ± SEM (n=5) b P < 0.01, c P < 0.001 and d P < 0.0001 are statistically significant in comparison to Tween-80 (Control) followed by unpaired t-test of one-way ANOVA (GraphPad Prism 7).